Helen Angell is a Principal Scientist in the Oncology, Translational Science team in the IMED Biotech Unit in Cambridge, UK.英雄联盟投注app

Helen received her Ph.D. ‘Immune Modulation of the Tumour Microenvironment’ from the University of Nottingham School of Pharmacy, funded by AstraZeneca and EPSRC (Engineering and Physical Sciences Research Council). Upon completing her doctorate, Helen began working in the Laboratory of Integrative Immunology at the Cordeliers Research Centre, Paris. A joint MedImmune-funded postdoc, here Helen was involved in the development and implementation of the ‘Immunoscore’. In addition, Helen undertook research into the characterisation and phenotyping of immune subpopulations, cytokines, chemokines and tumour alteration, associated with colorectal cancer progression, recurrence and metastasis.

In January 2014 Helen joined AstraZeneca’s IMED Oncology Translational Science 团队. Since then Helen has focussed on development of the leading Immuno-Oncology 文件夹, devising strategies for segmentation of immunotherapy and small molecule combination studies with the aim to enhance patient selection for clinical trials, as well as leading external collaborations to further accelerate scientific progress in this field. This is exemplified by numerous publications, including Helen’s authorship on a recent high impact publication validating the use of Immunoscore for the classification of colon cancer. 



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LATEST PROJECT

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IMMUNE PROFILING STRATEGY

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IMMUNO-ONCOLOGY DISEASE POSITIONING FOR NOVEL INDICATIONS

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PLATFORM DEVELOPMENT FOR MEASUREMENT OF IMMUNE PARAMETERS

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GROUND-BREAKING PATIENT STRATIFICATION

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文章 PUBLISHED

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The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis英雄联盟投注app

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Bernhard Mlecnik, Gabriela Bindea, Amos Kirilovsky, Helen K. Angell, Anna C. Obenauf, Marie Tosolini, Sarah Church, Pauline Maby, Tessa Fredriksen, Stéphanie Mauger, Anne Berger, Michael R. Speicher, Franck Pagès, Viia Valge-Archer, Jérôme Galon. Science Translational Medicine, 2016.

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability英雄联盟投注app

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability. Bernhard Mlecnik, Gabriela Bindea, Helen K Angell, Pauline Maby, David Tougeron, Lucie Lafontaine, Mihaela Angelova, Tessa Fredriksen, Maristella Sasso, Amélie M. Bilocq, Anna C. Obenauf, Anne Berger, Patrick Bruneval, Florence Le Pessot, Arash Rafii, Michael R. Speicher, Zlatko Trajanoski, Richard Sesboüe, Thierry Frebourg, Franck Pagès, Viia Valge-Archer, Jean-Baptiste Latouche, Jérôme Galon. Immunity, 2016.

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy英雄联盟投注app

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy. Pauline Maby, David Tougeron, Bernhard Mlecnik, Mohamad Hamieh, Gabriela Bindea, Helen K Angell, Tessa Fredriksen, Nicolas Elie, Emilie Fauquembergue, Jacques Benichou, Florence Le Pessot, Richard Sesboue, Thierry Frebourg, Jerome Galon, Jean-Baptiste Latouche. Cancer Research, 2015.

CXCL13-CXCR5 Signalling Is Required for the Anti-Tumour Immune Response in Colorectal Cancer英雄联盟投注app

CXCL13-CXCR5 Signalling Is Required for the Anti-Tumour Immune Response in Colorectal Cancer. Maximilian J. Waldner, Gabriela Bindea, Bernhard Mlecnik, Helen K. Angell, Sebastian Foersch, Uta E. Höpken, Stefan J. Wirtz, Christoph Becker, Markus F. Neurath, Jérôme Galon. Gastroenterology, 2014.

Spatio-temporal dynamics of intratumoral cells reveal the immune landscape in human cancer英雄联盟投注app

Spatio-temporal dynamics of intratumoral cells reveal the immune landscape in human cancer.   Gabriela Bindea, Bernhard Mlecnik, Marie Tosolini, Amos Kirilovsky, Maximilian Waldner, Anna C. Obenauf, Helen K. Angell, Tessa Fredriksen, Lucie Lafontaine, Anne Berger, Patrick Bruneval, Wolf Herman Fridman, Christoph Becker, Franck Pagès, Michael R. Speicher, Zlatko Trajanoski, Jérôme Galon. Immunity, 2013.

The continuum of cancer immunosurveillance: Prognostic, predictive and mechanistic signatures英雄联盟投注app

The continuum of cancer immunosurveillance: Prognostic, predictive and mechanistic signatures.  Jérôme Galon, Helen K. Angell, Davide Bedognetti, and Francesco Marincola.  Immunity, 2013.

Microenvironnement immunitaire et survie : l’Immunoscore英雄联盟投注app

Microenvironnement immunitaire et survie : l’Immunoscore. Jérôme Galon, Gabriela Bindea, Bernhard Mlecnik, Helen Angell, Christine Lagorce, Anne Berger, Franck Pagès. Medicine and Science,  2014. Epub 2014 May 5.

Functional network tailored pipeline revealed genetic determinants of tumours associated with in situ lymphocyte proliferation and survival of cancer patients英雄联盟投注app

Functional network tailored pipeline revealed genetic determinants of tumours associated with in situ lymphocyte proliferation and survival of cancer patients.  Bernhard Mlecnik, Gabriela Bindea, Helen K. Angell, Maria Stella Sasso, Anna C. Obenauf, Tessa Fredriksen, Lucie Lafontaine, Amelie M. Bilocq, Amos Kirilovsky, Marie Tosolini, Anne Berger, Wolf Herman Fridman, Arash Rafii, Viia Valge-Archer, Franck Pagès, Michael R. Speicher, Jérôme Galon. Science Translational Medicine, 2014.

The immune landscape of human tumors英雄联盟投注app

The immune landscape of human tumors. Gabriela Bindea, Bernhard Mlecnik, Helen K Angell, Jérôme Galon. Oncoimmunology, 2014.

Towards the introduction of the Immunoscore in the classification of malignant tumors英雄联盟投注app

Towards the introduction of the Immunoscore in the classification of malignant tumors. Jérôme Galon, Bernhard Mlecnik, Gabriela Bindea, Helen K Angell, Anne Berger, et al. Journal of Pathology, 2014.

Spatio-temporal dynamics of intratumoral cells reveal the immune landscape in human cancer英雄联盟投注app

Gabriela Bindea, Bernhard Mlecnik, Marie Tosolini, Amos Kirilovsky, Maximilian Waldner, Anna C. Obenauf, Helen K. Angell, Tessa Fredriksen, Lucie Lafontaine, Anne Berger, Patrick Bruneval, Wolf Herman Fridman, Christoph Becker, Franck Pagès, Michael R. Speicher, Zlatko Trajanoski, Jérôme Galon. Immunity, 2013.

Digital pattern recognition based image analysis enables reliable quantification of immune infiltrates in distinct tissue regions of colorectal cancer and identifies a potential metastatic phenotype英雄联盟投注app

Digital pattern recognition based image analysis enables reliable quantification of immune infiltrates in distinct tissue regions of colorectal cancer and identifies a potential metastatic phenotype.  H.K. Angell, N. Gray, C. Womack, D.I. Pritchard, R.W. Wilkinson, M. Cumberbatch. British Journal Cancer, 2013.

The continuum of cancer immunosurveillance: Prognostic, predictive and mechanistic signatures英雄联盟投注app

The continuum of cancer immunosurveillance: Prognostic, predictive and mechanistic signatures.  Jérôme Galon, Helen K. Angell, Davide Bedognetti, and Francesco Marincola.  Immunity, 2013.

From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer英雄联盟投注app

From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer.  Helen Angell and Jérôme Galon.  Current Opinion in Immunology, 2013.

Cancer classification using the Immunoscore: A worldwide task force英雄联盟投注app

Cancer classification using the Immunoscore: A worldwide task force.  Jérôme Galon, Franck Pagès, Francesco M Marincola, Helen K Angell, et al. Journal Translational Medicine, 2012.

A study into the potential role of Survivin localization in resistance to drug-induced apoptosis英雄联盟投注app

A study into the potential role of Survivin localization in resistance to drug-induced apoptosis. Angell, H. Bioscience Horizons, 2008.

TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: a Cellomics analysis英雄联盟投注app

TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: a Cellomics analysis. Dawes LJ, Angell H, Sleeman M, Reddan JR, Wormstone IM. Experimental Eye Research, 2007.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.英雄联盟投注app

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. The Lancet, 2018. Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, P Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E Church, Helen K Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Je rey P Meyers, Christopher Paustian, Zipei Feng, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Daniel J Sargent*, Bernard A Fox, Jérôme Galon


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AstraZeneca’s progress in the immuno-oncology field fills me with great excitement! Our emerging data will help us to identify and validate patient biomarkers and potential therapeutic targets, which may enable better treatment decisions, as well as potentially providing novel opportunities with our advancing DNA Damage Response 文件夹.

Helen Angell Associate Principal Scientist, IMED Oncology, Translational Science

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